c-IAP1 (F7C3U) Rabbit Monoclonal Antibody (trFluor™ Europium Cryptate Conjugate) #20330
- ELISA+
Product Specifications
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- ELISA+-ELISA and/or ELISA-like Assays
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Description
Product Usage Information
Note: Addition of potassium fluoride (KF) in the assay dilution buffer range of 40-400 mM is recommended for enhanced fluorescent signal. Optimal dilutions and working concentrations of both the conjugated antibodies and the KF should be determined by the end user.
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
c-IAP1 (gene name: BIRC2), which is structurally and functionally closely related to c-IAP2 (gene name: BIRC3), also contains a RING domain that confers E3 ubiquitin ligase activity (7). c-IAP1 is recruited to the TNF receptor complex upon ligand binding and functions as a positive regulator of the canonical NF-κB signaling pathway, leading to autoubiquitination as well as ubiquitination of other signaling targets, including RIP1 and TRAF family members (8-11). c-IAP is frequently overexpressed in many cancers, contributing to tumorigenesis by inhibiting apoptosis (12,13). IAP inhibitors, like Smac mimetics, can result in c-IAP1 degradation and have been pursued as therapeutic opportunities (14).
- Deveraux, Q.L. and Reed, J.C. (1999) Genes Dev 13, 239-52.
- Deveraux, Q.L. et al. (1998) EMBO J 17, 2215-23.
- Altieri, D.C. et al. (1999) Lab Invest 79, 1327-33.
- Tamm, I. et al. (2000) Clin Cancer Res 6, 1796-803.
- Kasof, G.M. and Gomes, B.C. (2001) J Biol Chem 276, 3238-46.
- Deveraux, Q.L. et al. (1997) Nature 388, 300-4.
- Rothe, M. et al. (1995) Cell 83, 1243-52.
- Yang, Y. et al. (2000) Science 288, 874-7.
- Varfolomeev, E. et al. (2008) J Biol Chem 283, 24295-9.
- Li, X. et al. (2002) Nature 416, 345-7.
- Mao, A.P. et al. (2010) J Biol Chem 285, 9470-9476.
- LaCasse, E.C. et al. (1998) Oncogene 17, 3247-59.
- Tamm, I. et al. (2000) Clin Cancer Res 6, 1796-803.
- Feltham, R. et al. (2011) J Biol Chem 286, 17015-28.
Alternate Names
API1; apoptosis inhibitor 1; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; Baculoviral IAP repeat-containing protein 2; BIRC2; C-IAP1; Cellular inhibitor of apoptosis 1; cIAP1; hIAP-2; hIAP2; IAP homolog B; IAP-2; IAP2; Inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; RNF48; TNFR2-TRAF-signaling complex protein 2
Limited Uses
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