CDX2 (D11D10) Rabbit mAb (Alexa Fluor® 555 Conjugate) #84638
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Immunofluorescence (Immunocytochemistry) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
CDX2 (D11D10) Rabbit mAb (Alexa Fluor® 555 Conjugate) recognizes endogenous levels of total CDX2 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDX2 protein.
Background
CDX2, a homeobox domain-containing transcription factor, is a master regulator of the trophectoderm, the layer that gives rise to extra-embryonic tissues in mammalian development (1). CDX2 is also involved in intestinal development (2), and gain of expression or loss of expression has been associated with various human malignancies, such as Barrett's esophagus (3) and colorectal cancer (4,5). Mouse embryonic stem cells deficient in CDX2 display limited hematopoietic progenitor development and altered Hox gene expression (6), pointing to a role for CDX2 in Hox gene regulation. CDX2 is also implicated in the aberrant expression of Hox genes in human AML cell lines (7).
- Ralston, A. and Rossant, J. (2008) Dev Biol 313, 614-29.
- Traber, P.G. and Silberg, D.G. (1996) Annu Rev Physiol 58, 275-97.
- Shi, X.Y. et al. (2008) Am J Clin Pathol 129, 571-7.
- Bakaris, S. et al. (2008) Histol Histopathol 23, 1043-7.
- Guo, R.J. et al. (2004) Cancer Biol Ther 3, 593-601.
- Wang, Y. et al. (2008) Proc Natl Acad Sci U S A 105, 7756-61.
- Fröhling, S. et al. (2007) Cell Cycle 6, 2241-5.
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