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9283
MNDA (3C1) Rat mAb (Alexa Fluor® 488 Conjugate)
Antibody Conjugates

MNDA (3C1) Rat mAb (Alexa Fluor® 488 Conjugate) #9283

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Supporting Data

REACTIVITY
SENSITIVITY
MW (kDa)
Isotype Rat 

Application Key:

  • W-Western
  • IP-Immunoprecipitation
  • IHC-Immunohistochemistry
  • ChIP-Chromatin Immunoprecipitation
  • IF-Immunofluorescence
  • F-Flow Cytometry
  • E-P-ELISA-Peptide

Species Cross-Reactivity Key:

  • H-Human
  • M-Mouse
  • R-Rat
  • Hm-Hamster
  • Mk-Monkey
  • Mi-Mink
  • C-Chicken
  • Dm-D. melanogaster
  • X-Xenopus
  • Z-Zebrafish
  • B-Bovine
  • Dg-Dog
  • Pg-Pig
  • Sc-S. cerevisiae
  • Ce-C. elegans
  • Hr-Horse
  • All-All Species Expected

Product Description

This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 488 fluorescent dye and tested in-house for direct flow cytometric analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated MNDA (3C1) Rat mAb #3329.

Storage:

Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.

Specificity / Sensitivity

MNDA (3C1) Rat mAb (Alexa Fluor® 488 Conjugate) detects endogenous levels of total MNDA protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a nuclear extract from human granulocytes.

Background

MNDA (myeloid cell nuclear differentiation antigen) is a transcription factor constitutively expressed in peripheral blood granulocytes and monocytes; low expression is also found in a subset of B cells (1,2). MNDA is a member of the interferon (IFN)-regulated 200 family of genes, which contain one or more copies of a partially conserved domain of 200 amino acid residues thought to mediate protein-protein interaction (3). MNDA may play a role in apoptosis and its expression is reduced in myelodysplastic syndromes (MDS) (4). MNDA has been proposed to be a marker for nodal marginal zone lymphoma (5).

  1. Briggs, R.C. et al. (1994) J Cell Biochem 56, 559-67.
  2. Miranda, R.N. et al. (1999) Hum Pathol 30, 1040-9.
  3. Landolfo, S. et al. (1998) Biochimie 80, 721-8.
  4. Briggs, R.C. et al. (2006) Cancer Res 66, 4645-51.
  5. Kanellis, G. et al. (2009) Leukemia 23, 1847-57.

Pathways & Proteins

Explore pathways + proteins related to this product.

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
The Alexa Fluor dye antibody conjugates in this product are sold under license from Life Technologies Corporation for research use only, except for use in combination with DNA microarrays. The Alexa Fluor® dyes (except for Alexa Fluor® 430 dye) are covered by pending and issued patents. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

To Purchase # 9283