|Purity||A greater than or equal to 95% purity was determined by SDS-PAGE.|
|Endotoxin||Endotoxin levels are less than or equal to 1 EU / 1 μg hFGF-6.|
|Activity||The bioactivity of recombinant hFGF-6 was determined in an NR6R-3T3 cell proliferation assay. The ED50 of each lot is less than or equal to 1 ng/mL.|
Recombinant human FGF-6 was expressed in E. coli and is supplied in a lyophilized form.
FGF-6 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-6 binds to receptor FGFR4 and functions as a signaling molecule that is involved in many important processes (1,2). The mouse homolog of this gene exhibits predominantly in the myogenic lineage which suggests a role in muscle regeneration or differentiation (3,4). FGF-6 was able to transform NIH/3T3 cells and the resulting transformant formed a well-vascularized tumor in nude mice, thus suggesting an angiogenic property similar to some other members of the FGF family (4).
UniProt ID: P10767
Entrez-Gene Id: 2251
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