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87477
Human IL-16 Recombinant Protein
Cytokines & Growth Factors
Growth Factors and Cytokines

Human IL-16 Recombinant Protein #87477

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Human IL-16 Recombinant Protein: Image 1
The purity of Human IL-16 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant hIL-16 and staining with Coomassie Blue.

Storage

Human IL-16 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

Product Description

MW (kDa) 13.4
Purity A greater than or equal to 95% purity was determined by SDS-PAGE.
Endotoxin Endotoxin levels are less than or equal to 1 EU / 1 μg hIL-16.

Source / Purification

Recombinant human IL-16 was expressed in E. coli and is supplied in a lyophilized form.

Background

Interleukin 16 (IL-16) is pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication (1-4). IL-16 is associated with the development of multiple sclerosis, an inflammatory demyelinating disease of the central nervous system (5). Studies have shown that there is increased expression of IL-16 in the brain and spinal cord tissues of experimental autoimmune encephalomyelitis (EAE) mice compared to immunized controls. This resulted in recruitment and activation of CD4+ immune cells in the neuroinflammation associated with multiple sclerosis (5). IL-16 is a 17 kDa peptide that interacts with its receptor, the CD4 antigen, and functions as a growth factor specifically for CD4+ T cells. This pleiotropic cytokine is known to play a role in immunodeficiency diseases, such as AIDS (6).
  1. Cruikshank, W. and Center, D.M. (1982) J Immunol 128, 2569-74.
  2. Center, D.M. et al. (1983) J Immunol 131, 1854-9.
  3. Shimokawa, Y. et al. (1984) Immunology 51, 275-85.
  4. Cruikshank, W.W. et al. (2000) J Leukoc Biol 67, 757-66.
  5. Hridi, S.U. et al. (2021) Biology (Basel) 10, 472. doi: 10.3390/biology10060472.
  6. Cruikshank, W.W. et al. (1998) Int Rev Immunol 16, 523-40.

Pathways & Proteins

Explore pathways + proteins related to this product.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 87477
Cat. # Size Qty. Price
87477S
10 µg
$ 215