Render Target: STATIC
Render Timestamp: 2024-12-12T11:15:35.816Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-20 06:23:19.550
Product last modified at: 2024-06-27T13:37:04.817Z
Cell Signaling Technology Logo
1% for the planet logo
PDP - Template Name: Growth Factors and Cytokines
PDP - Template ID: *******9ad1159

Human IL-16 Recombinant Protein #87477

    Product Information

    Storage

    Human IL-16 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

    Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.

    Product Description

    MW (kDa) 13.4
    Purity A greater than or equal to 95% purity was determined by SDS-PAGE.
    Endotoxin Endotoxin levels are less than or equal to 1 EU / 1 μg hIL-16.

    Source / Purification

    Recombinant human IL-16 was expressed in E. coli and is supplied in a lyophilized form.

    Background

    Interleukin 16 (IL-16) is pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication (1-4). IL-16 is associated with the development of multiple sclerosis, an inflammatory demyelinating disease of the central nervous system (5). Studies have shown that there is increased expression of IL-16 in the brain and spinal cord tissues of experimental autoimmune encephalomyelitis (EAE) mice compared to immunized controls. This resulted in recruitment and activation of CD4+ immune cells in the neuroinflammation associated with multiple sclerosis (5). IL-16 is a 17 kDa peptide that interacts with its receptor, the CD4 antigen, and functions as a growth factor specifically for CD4+ T cells. This pleiotropic cytokine is known to play a role in immunodeficiency diseases, such as AIDS (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.