|Purity||A greater than or equal to 95% purity was determined by SDS-PAGE.|
|Endotoxin||Endotoxin levels are less than or equal to 1 EU / 1 μg hIL-17A/F.|
|Activity||The bioactivity of recombinant human IL-17A/F was determined by measuring the production of IL-6 from mouse 3T3 cells. The ED50 of each lot is less than or equal to 10 pg/mL.|
Recombinant human IL-17A/F was expressed in E. coli and is supplied in a lyophilized form.
IL-17A/F is a cystine-linked heterodimer of IL-17A and IL-17F (1,2). IL-17A/F is produced by Th17 cells and γδ T cells (1,2). IL-17A/F stimulates production of pro-inflammatory cytokines and neutrophil chemoattractants, thereby functioning as a bridge between adaptive and innate immunity (1-3). Some research studies suggest that IL-17A/F may be involved in mucosal immunity against some bacterial infections and has a putative role in some autoimmune disorders (3,4). The receptor for IL-17A/F consists of a heterodimer of IL-17RA and IL-17RC and signaling through this receptor leads to activation of the Erk1/2 and NF-κB pathways (1).
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