Human Interleukin-17F (hIL-17F) #8906
Inquiry Info. # 8906
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Product Information
Formulation
Storage
Maintain sterility. Storage at -20°C should be in a manual defrost freezer.
Product Description
| MW (kDa) | 15 |
| Purity | >98% as determined by SDS-PAGE of 6 μg reduced (+) and non-reduced (-) recombinant hIL-17F. All lots are greater than 98% pure. |
| Endotoxin | Less than 0.01 ng endotoxin/1 μg hIL-17F. |
| Activity | The bioactivity of recombinant hIL-17F was determined by its ability to induce mouse IL-6 production by 3T3 MEFs WT. The ED50 of each lot is between 30-80 ng/ml. |
| Molecular Formula | Recombinant hIL-17F contains no "tags" and the nonglycosylated protein has a calculated MW of 14,903. DTT-reduced protein migrates as a 22 kDa polypeptide. Lower mobility in SDS-PAGE is due to glycosylation. The non-reduced cystine-linked homodimer migrates as a 38 kDa protein. The expected amino-terminal RKIPK of recombinant hIL-17F was verified by amino acid sequencing. |
Source / Purification
Background
- Kolls, J.K. and Lindén, A. (2004) Immunity 21, 467-76.
- Liang, S.C. et al. (2006) J Exp Med 203, 2271-9.
- Kuestner, R.E. et al. (2007) J Immunol 179, 5462-73.
- Kawaguchi, M. et al. (2002) J Biol Chem 277, 15229-32.
- Zrioual, S. et al. (2009) J Immunol 182, 3112-20.
- Ishigame, H. et al. (2009) Immunity 30, 108-19.
Alternate Names
hIL-17F; il-17f; IL17
Limited Uses
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