Cleaved Caspase-3 (Asp175) Blocking Peptide #1050
Pricing & Additional Information
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Important Ordering Details
Custom Ordering Details: This product is assembled upon order. Please allow two-four weeks for your product to be processed.Product Information
Product Usage Information
Use as a blocking reagent to evaluate the specificity of antibody reactivity in dot blot protocols.
Storage
Product Description
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide reacts with Cleaved Caspase-3 (Asp175) (D3E9) Rabbit mAb #9579 by dot blot.
Background
Caspase-3 (CPP-32, Apopain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position (2).
Limited Uses
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