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41965
SignalSlide® Mouse PD-L1 IHC Controls
Experimental Controls
IHC Control Slides

SignalSlide® Mouse PD-L1 IHC Controls #41965

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SignalSlide® Mouse PD-L1 IHC Controls: Image 1

Immunohistochemical analysis of paraffin-embedded Raw 264.7 cell pellet (left, negative) or mouse bone marrow-derived macrophages cell pellet (right, positive) using PD-L1 (D5V3B) (Mouse specific; IHC specific) Rabbit mAb #64988.

To Purchase # 41965S
Product # Size Price
41965S
1 Pack  (5 slides) $ 144

Important Ordering Details

Custom Ordering Details: Sections are cut freshly upon ordering. Please allow up to three business days for your product to be processed.

Product Description

Each control slide contains formalin fixed, paraffin-embedded cell pellets: Raw 264.7 (mPD-L1 negative) and mouse bone marrow-derived macrophages (mPD-L1 positive), which serve as controls for mPD-L1 immunostaining.

Background

Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor-infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).

  1. Dong, H. et al. (1999) Nat Med 5, 1365-9.
  2. Freeman, G.J. et al. (2000) J Exp Med 192, 1027-34.
  3. Liang, S.C. et al. (2003) Eur J Immunol 33, 2706-16.
  4. Dong, H. et al. (2002) Nat Med 8, 793-800.
  5. Thompson, R.H. et al. (2006) Cancer Res 66, 3381-5.
  6. Pardoll, D.M. (2012) Nat Rev Cancer 12, 252-64.
  7. Taube, J.M. et al. (2012) Sci Transl Med 4, 127ra37.
  8. Lyford-Pike, S. et al. (2013) Cancer Res 73, 1733-41.
  9. Chen, B.J. et al. (2013) Clin Cancer Res 19, 3462-73.

Pathways & Proteins

Explore pathways + proteins related to this product.

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