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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CIRBP Antibody recognizes endogenous levels of total CIRBP protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly150 of human CIRBP protein. Antibodies are purified by protein A and peptide affinity chromatography.

Cold-induced RNA-binding protein (CIRBP) is a 172-residue, multifunctional sensor protein that was first isolated as a protein induced in mouse fibroblasts cultured at 32ºC (1). Conversely, CIRBP expression decreases in cells or tissues subjected to increased temperature (2). The CIRBP protein is composed of an amino-terminal RNA-binding domain and a carboxyl-terminal, glycine-rich domain (1). Stressful stimuli, such as hypoxia, heat shock, osmotic shock, or oxidative conditions, lead to translocation of CIRBP from the nucleus to cytoplasmic stress granules through a mechanism involving CIRBP methylation-dependent nuclear export (3). CIRBP plays a role in regulating apoptosis and preserving the stemness of neural stem cells at moderately low temperatures (4). Research studies demonstrate that CIRBP contributes to the regulation of circadian rhythm through post-translational modulation of CLOCK expression (5).

1.  Nishiyama, H. et al. (1997) J Cell Biol 137, 899-908.

2.  Nishiyama, H. et al. (1998) Am J Pathol 152, 289-96.

3.  De Leeuw, F. et al. (2007) Exp Cell Res 313, 4130-44.

4.  Saito, K. et al. (2010) Brain Res 1358, 20-9.

5.  Morf, J. et al. (2012) Science 338, 379-83.

Entrez-Gene Id 1153
Swiss-Prot Acc. Q14011

For Research Use Only. Not For Use In Diagnostic Procedures.
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Tween is a registered trademark of ICI Americas, Inc.

CIRBP Antibody