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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Kindlin-3 Antibody recognizes endogenous levels of total kindlin-3 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly649 of human kindlin-3 protein. Antibodies are purified by protein A and peptide affinity chromatography.

The kindlin family of focal adhesion proteins is involved in multiple biological processes, including integrin signaling, adhesion, migration, angiogenesis, differentiation, and mitotic spindle formation (1,2). Kindlin family members 1, 2, and 3 (FERM1, FERM2, and URP2) are differentially expressed in tissues. Kindlin-1 is primarily expressed in epithelial cells, kindlin-2 is ubiquitously expressed, and kindlin-3 expression is restricted to the hematopoietic system (3).

Kindlin-3 (FERMT3 or URP2) is a member of the kindlin family of focal adhesion proteins, which plays an essential role in integrin activation and in various immune functions (3,4). Kindlin-3 is mainly expressed in the hematopoietic system (5). Kindlin-3, together with talin, binds to the cytoplasmic tail of β-integrin and activates integrin-mediated signaling cascades (6-8). Research studies identified mutations of Kindlin-3 that cause a rare hereditary human disease, leukocyte-adhesion deficiency (LAD) type III (9,10).

1.  Ye, F. and Petrich, B.G. (2011) Curr Opin Hematol 18, 356-60.

2.  Meves, A. et al. (2009) Trends Cell Biol 19, 504-13.

3.  Karaköse, E. et al. (2010) J Cell Sci 123, 2353-6.

4.  Fagerholm, S.C. et al. (2014) Am J Clin Exp Immunol 3, 37-42.

5.  Pasini, E.M. et al. (2006) Blood 108, 791-801.

6.  Tadokoro, S. et al. (2003) Science 302, 103-6.

7.  Wegener, K.L. et al. (2007) Cell 128, 171-82.

8.  Moser, M. et al. (2009) Science 324, 895-9.

9.  Malinin, N.L. et al. (2009) Nat Med 15, 313-8.

10.  Svensson, L. et al. (2009) Nat Med 15, 306-12.

Entrez-Gene Id 83706
Swiss-Prot Acc. Q86UX7

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Kindlin-3 Antibody