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HRS Antibody

HRS Antibody #14346

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
  • IF
H M Mk

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

HRS Antibody recognizes endogenous levels of total HRS protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly670 of human HRS protein. Antibodies are purified by protein A and peptide affinity chromatography.

Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) is a ubiquitously expressed, multidomain-containing protein that is tyrosine phosphorylated upon activation of multiple receptor tyrosine kinases (1). HRS contains a proline-rich region, which may mediate interactions with SH3 domain-containing proteins (1). Research studies have also demonstrated that HRS possesses a phosphatidylinositol 3-phosphate-binding FYVE-type zinc finger domain and a coiled-coil domain that target it to membranes of the endosomal compartment (2-4). HRS also possesses a ubiquitin-interacting motif (UIM) that binds ubiquitinated membrane proteins and, in conjunction with Eps15 and STAM proteins of the ESCRT-0 complex, facilitates their sorting through the endosomal compartment for eventual degradation in the lysosome (5-8). Research studies demonstrate that phosphorylation and ubiquitination of HRS play a role in EGFR intracellular trafficking and degradation (9,10).

  1. Komada, M. and Kitamura, N. (1995) Mol Cell Biol 15, 6213-21.
  2. He, J. et al. (2009) Proteins 76, 852-60.
  3. Raiborg, C. et al. (2001) J Cell Sci 114, 2255-63.
  4. Komada, M. et al. (1997) J Biol Chem 272, 20538-44.
  5. Raiborg, C. et al. (2002) Nat Cell Biol 4, 394-8.
  6. Hirano, S. et al. (2006) Nat Struct Mol Biol 13, 272-7.
  7. Bache, K.G. et al. (2003) J Biol Chem 278, 12513-21.
  8. Urbé, S. et al. (2003) J Cell Sci 116, 4169-79.
  9. Stern, K.A. et al. (2007) Mol Cell Biol 27, 888-98.
  10. Tan, X. et al. (2015) EMBO J 34, 475-90.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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