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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Trf2 Antibody detects endogenous levels of Trf2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide correspoding to residues near the carboxy terminus of human Trf2. Antibodies are purified by protein A and peptide affinity chromatography.

Telomeres, the linear ends of chromosomes, are organized into T-loops to prevent them from being recognized by the cell as DNA double stranded breaks (DSBs) (1). The telomeric repeat binding factor proteins TRF1 and TRF2 bind to double-stranded telomeres to allow formation of T-loops (2). A large number of proteins involved in the DNA damage response are found physically associated with TRF2 within telomeres (3). Interestingly, TRF2 can transiently localize to DNA damage-induced DSBs, but overexpression of TRF2 prevents ATM-dependent signaling (4). Phosphorylation of TRF2 at Ser323 has been reported in vivo, but no upstream kinase or role has been established for this phosphorylation site (5).

1.  Karlseder, J. et al. (1999) Science 283, 1321-5.

2.  Yoshimura, S.H. et al. (2004) Genes Cells 9, 205-18.

3.  Colgin, L. and Reddel, R. (2004) Curr Biol 14, R901-2.

4.  Bradshaw, P.S. et al. (2005) Nat Genet 37, 193-7.

5.  Beausoleil, S.A. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 12130-12135.

Entrez-Gene Id 7014
Swiss-Prot Acc. Q15554

For Research Use Only. Not For Use In Diagnostic Procedures.
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Trf2 Antibody