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100 Mouse 

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CD10 (CB-CALLA) Mouse mAb detects endogenous levels of CD10.

Source / Purification

Monoclonal antibody is produced by immunizing BALB/c mice with CALLA cells.

CD10 (CALLA or neprilysin) was identified as a marker for leukemic cells in children with acute lymphoblastic leukemia and belongs to a family of exoenzymes that include aminopeptidase A, N and dipeptidylpeptidase IV (1-2). CD10 is a transmembrane type II molecule and functions as a metallo-peptidase requiring zinc. Specifically, CD10 cleaves 1-3 amino-terminal amino acids from peptides with a preference for neutral amino acids (valine, iso-leucine, phenylalanine, leucine or alanine) (2). The CD10 antigen is expressed by immature and by germinal center B cells, by granulocytes and by acute B-cell lymphoblastic leukemia cells. Therefore, CD10 appears to be involved in late stage regulation of hematopoietic cells (3).

1.  Greaves , M. F. et al. (1975) Clin. Immunol. Immunopathol. 4, 67-84.

2.  Shipp, M.A. and Look, A.T. (1993) Blood 82, 1052-1070.

3.  Bene, M. C. et al. (1997) Haematologica. 82, 205-210.

Entrez-Gene Id 4311
Swiss-Prot Acc. P08473

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

CD10 (CB-CALLA) Mouse mAb