Upstream / Downstream
Explore pathways related to this product.
Our U.S. Offices Are Closed
Our U.S. offices are closed in observance of Memorial Day. We will reopen on Tuesday, May 30th.
Thank you for your patience.
Find answers on our FAQs page.
- Additional protein information
- Analytical tools
GATA-6 (A549) Antibody #4253
This product is discontinued
Gallery: GATA-6 (A549) Antibody #4253
GATA-6 (A549) Antibody detects endogenous levels of total GATA-6 protein.
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acid sequence surrounding Ala549 of human GATA-6 protein, isoform 1. Antibodies are purified by protein A and peptide affinity chromatography.
GATA proteins comprise a group of transcription factors that are related by the presence of conserved zinc finger DNA binding domains, which bind directly to the nucleotide sequence core element GATA (1-3). There are six vertebrate GATA proteins, designated GATA-1 to GATA-6 (3).
GATA-6 plays a critical role in endoderm development (4). It is essential for development of the heart, gut and other organs (5,6). Knock out of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm (4). Loss of expression, or loss of nuclear localization of GATA-6 is apparent in a large number of ovarian tumors (7).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.