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55 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

GATA-6 (A549) Antibody detects endogenous levels of total GATA-6 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acid sequence surrounding Ala549 of human GATA-6 protein, isoform 1. Antibodies are purified by protein A and peptide affinity chromatography.

GATA proteins comprise a group of transcription factors that are related by the presence of conserved zinc finger DNA binding domains, which bind directly to the nucleotide sequence core element GATA (1-3). There are six vertebrate GATA proteins, designated GATA-1 to GATA-6 (3).

GATA-6 plays a critical role in endoderm development (4). It is essential for development of the heart, gut and other organs (5,6). Knock out of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm (4). Loss of expression, or loss of nuclear localization of GATA-6 is apparent in a large number of ovarian tumors (7).

1.  Ko, L.J. and Engel, J.D. (1993) Mol Cell Biol 13, 4011-22.

2.  Merika, M. and Orkin, S.H. (1993) Mol Cell Biol 13, 3999-4010.

3.  Lowry, J.A. and Atchley, W.R. (2000) J Mol Evol 50, 103-15.

4.  Cai, K.Q. et al. (2008) Dev Dyn 237, 2820-9.

5.  Charron, F. and Nemer, M. (1999) Semin Cell Dev Biol 10, 85-91.

6.  Haveri, H. et al. (2008) BMC Gastroenterol 8, 9.

7.  Caslini, C. et al. (2006) Oncogene 25, 5446-61.

Entrez-Gene Id 2627
Swiss-Prot Acc. Q92908

For Research Use Only. Not For Use In Diagnostic Procedures.
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GATA-6 (A549) Antibody