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4485
PTPmu (BK2) Mouse mAb

PTPmu (BK2) Mouse mAb #4485

This product is discontinued

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

PTPmu Mouse mAb detects endogenous levels of total PTPmu protein. This antibody does not cross react with other receptor tyrosine phosphatases.

Species predicted to react based on 100% sequence homology:

Mouse

Monoclonal antibody (isotype: IgG2a) is produced by immunizing mice with a synthetic peptide corresponding to the amino-terminal residues of human PTPmu.

Receptor tyrosine phosphatase PTPmu has an extracellular segment characteristic of adhesion molecules: an MEM domain, an Ig domain and four fibronectin III like (FN III) repeats (1,2). PTPmu is proteolytically cleaved into two noncovalently associated fragments: one is the extracellular domain, the other includes the transmembrane and the intracellular catalytic domains. Both fragments are approximately 100 kDa (3). The extracellular domain mediates cell-cell adhesion in a homophilic, Ca2+ independent manner (1,2). PTPmu associates with multiple cadherins (4). It is able to restore E-cadherin-dependent adhesion in human prostate cancer, and is required for N-cadherin-mediated neurite outgrowth (5,6). The phosphatase activity seems to be essential for the latter function but is dispensable for the former (5,6). PTPmu also associates with and recruits a scaffold protein, RACK (receptor for activated protein C kinase), to cell-cell contact sites (7). Both PKCdelta and src seem to be involved in this process (6,7).

  1. Gebbink, M. F. et al. (1993) J. Biol. Chem. 268, 16101-16104.
  2. Brady-Kalnay, S.M. and Tonks, N.K. (1994) J. Biol. Chem. 269, 28472-28477.
  3. Brady-Kalnay, S. M. et al. (1998) J. Cell Biol. 141, 287-296.
  4. Hellberg, C. B. et al. (2002) J. Biol. Chem. 277, 11165-11173.
  5. Burden-Gulley, S.M. and Brady-Kalnay, S.M. (1999) J. Cell Biol. 144, 1323-1336.
  6. Mourton, T. et al. (2001) J. Biol. Chem. 276, 14896-14901.
Entrez-Gene Id
5797
Swiss-Prot Acc.
P28827
For Research Use Only. Not For Use In Diagnostic Procedures.

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