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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

IL-17RA Antibody recognizes endogenous levels of total IL-17RA protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val790 of human IL-17RA protein. Antibodies are purified by protein A and peptide affinity chromatography.

The IL-17 family of cytokines consists of IL-17A-F, and their receptors include IL-17RA-RE (1). IL-17 cytokines are produced by a variety of cell types including the Th17 subset of CD4+ T cells, as well as subsets of γδ T cells, NK cells, and NKT cells (2). IL-17A and IL-17F, the most well-studied of the IL-17 cytokines, contribute to fungal and bacterial immunity by inducing expression of proinflammatory cytokines, chemokines, and antimicrobial peptides (2). In addition, IL-17A contributes to the pathogenesis of several autoimmune diseases (3). IL-17E promotes Th2 cell responses (4). The roles of IL-17B, IL-17C, and IL-17D are less clear, however these family members also appear to have the capacity to induce proinflammatory cytokines (1,5,6). IL-17 receptors have an extracellular domain, a transmembrane domain, and a SEFIR domain. They are believed to signal as homodimers, heterodimers, or multimers through their SEFIR domain by recruiting the SEFIR domain-containing adaptor Act1 (7). Unlike most cytokines that signal through Jak/STAT pathways, IL-17 signaling results in NF-κB activation (8).

IL-17RA associates with IL-17RC to mediate signaling by homodimers and heterodimers of IL-17A and IL-17F (9,10). IL-17RA is broadly expressed, with highest expression in hematopoietic cells (11).

1.  Gaffen, S.L. (2009) Nat Rev Immunol 9, 556-67.

2.  Iwakura, Y. et al. (2011) Immunity 34, 149-62.

3.  Hu, Y. et al. (2011) Ann N Y Acad Sci 1217, 60-76.

4.  Fort, M.M. et al. (2001) Immunity 15, 985-95.

5.  Yamaguchi, Y. et al. (2007) J Immunol 179, 7128-36.

6.  Li, H. et al. (2000) Proc Natl Acad Sci U S A 97, 773-8.

7.  Chang, S.H. et al. (2006) J Biol Chem 281, 35603-7.

8.  Shalom-Barak, T. et al. (1998) J Biol Chem 273, 27467-73.

9.  Toy, D. et al. (2006) J Immunol 177, 36-9.

10.  Wright, J.F. et al. (2008) J Immunol 181, 2799-805.

11.  Yao, Z. et al. (1995) Immunity 3, 811-21.

Entrez-Gene Id 23765
Swiss-Prot Acc. Q96F46

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IL-17RA Antibody