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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

PINK1 (N4/15.11) Mouse mAb recognizes transfected levels of total PINK1 protein. Endogenous levels of PINK1 have not been detected with this antibody so far.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PINK1 protein.

PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria (1-3). PINK1 phosphorylates Parkin and promotes its translocation to mitochondria (2). Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction (1,3).

1.  Liu, W. et al. (2009) PLoS One 4, e4597.

2.  Kim, Y. et al. (2008) Biochem Biophys Res Commun 377, 975-80.

3.  Petit, A. et al. (2005) J Biol Chem 280, 34025-32.

Entrez-Gene Id 65018
Swiss-Prot Acc. Q9BXM7

For Research Use Only. Not For Use In Diagnostic Procedures.
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PINK1 (N4/15.11) Mouse mAb