Render Target: STATIC
Render Timestamp: 2024-12-02T11:06:39.096Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-08-01 15:29:52.365
Product last modified at: 2024-11-13T12:45:14.794Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ACBP/DBI (E4V8V) XP® Rabbit mAb #40487

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 10
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:500 - 1:2000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ACBP/DBI (E4V8V) XP® Rabbit mAb recognizes endogenous levels of total ACBP/DBI protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant human ACBP/DBI protein.

    Background

    Acyl-CoA-binding protein (ACBP) binds to long-chain acyl-CoA molecules and regulates lipid metabolism. This protein is also known as diazepam-binding inhibitor (DBI) and binds to the benzodiazepine-binding site of the γ-aminobutyric acid (GABA) type A receptor (GABAAR), regulating its activity (1). ACBP/DBI is highly expressed in glioblastoma and promotes glioblastoma growth by providing long-chain acyl-CoA molecules to mitochondria for fatty acid oxidation. Reduced ACBP/DBI expression leads to slower proliferation of glioblastoma (2,3). In addition, ACBP/DBI is a regulator of neural progenitor and stem cell proliferation in adult mouse neurogenic niches (4,5). Studies show that ACBP/DBI modulates embryonic neurogenesis of excitatory and inhibitory neurons through GABA signaling (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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