Render Target: STATIC
Render Timestamp: 2024-10-14T10:11:31.810Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-06-11 20:01:10.615
Product last modified at: 2024-10-01T13:30:09.255Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

AIFM2/FSP1 Antibody #24972

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 41
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    AIFM2/FSP1 Antibody recognizes endogenous levels of total AIFM2/FSP1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human AIFM2/FSP1 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Apoptosis-inducing factor mitochondria-associated 2 (AIFM2), also known as AIF-homologous mitochondrion-associated inducer of death (AMID) or p53-responsive gene 3 (PRG3), is a homolog of apoptosis-inducing factor (AIF) (1,2). Research studies show that it inhibits ferroptosis, a form of cell death caused by iron-dependent lipid peroxidation. Therefore, this protein was named as ferroptosis suppressor protein 1 (FSP1). FSP1 is a coenzyme Q10 (CoQ) oxidoreductase and generates the reduced form of (CoQ), which traps lipid peroxides, leading to the suppression of ferroptosis. Furthermore, inhibition of ferroptosis by FSP1 was shown to be independent of GPX4, another negative regulator of ferroptosis (3,4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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