|8336T||1 Kit (9 x 20 microliters)||
|Phospho-ALK (Tyr1586) (3B4) Rabbit mAb 3348||20 µl||
||H||80 (NPM-ALK) 220 (ALK)||Rabbit IgG|
|Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb 5031||20 µl||
||H M||115||Rabbit IgG|
|Phospho-Jak2 (Tyr1007) (D15E2) Rabbit mAb 4406||20 µl||
||H M||125||Rabbit IgG|
|Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb 9145||20 µl||
||H M R Mk||79, 86||Rabbit IgG|
|Phospho-Stat5 (Tyr694) (D47E7) XP® Rabbit mAb 4322||20 µl||
||H M||90||Rabbit IgG|
|Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb 4370||20 µl||
||H M R Hm Mk Mi Dm Z B Dg Pg Sc||44, 42||Rabbit IgG|
|Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb 4060||20 µl||
||H M R Hm Mk Dm Z B||60||Rabbit IgG|
|Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb 6943||20 µl||
||H M R Mk||60||Rabbit IgG|
|Phospho-PLCγ1 (Tyr783) (D6M9S) Rabbit mAb 14008||20 µl||
||H M||155||Rabbit IgG|
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Rabbit monoclonal antibodies are produced by immunizing animals with synthetic phosphopeptides corresponding to residues surrounding Tyr1586 of human ALK, Tyr1007 of human Jak2, Tyr980/981 of human and mouse Jak3, Tyr705 of mouse Stat3, Tyr694 of human Stat5a, Thr202/Tyr204 of human p44 MAP kinase, Ser473 of human Akt, Tyr416 of human Src, or Tyr783 of human PLCγ1 protein.
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development (1-3). In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, and PI3 kinase (1). ALK was originally discovered as a nucleophosmin (NPM)-ALK fusion protein produced by a translocation (4). Investigators have found that the NPM-ALK fusion protein is a constitutively active, oncogenic tyrosine kinase associated with anaplastic lymphoma (4). Research literature suggests that activation of PLCγ by NPM-ALK may be a crucial step for its mitogenic activity and involved in the pathogenesis of anaplastic lymphomas (5).
A distinct ALK oncogenic fusion protein involving ALK and echinoderm microtubule-associated protein like 4 (EML4) has been described in the research literature from a non-small cell lung cancer (NSCLC) cell line, with corresponding fusion transcripts present in some cases of lung adenocarcinoma. The short, amino-terminal region of the microtubule-associated protein EML4 is fused to the kinase domain of ALK (6-8).
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UniProt ID: P40763 , P27361 , P31751 , Q9Y243 , P07947 , P07948 , Q9UM73 , P42229 , P51692 , P28482 , P06239 , P19174 , P31749 , P08631 , P12931 , P52333 , P06241 , O60674
Entrez-Gene Id: 6774 , 5595 , 208 , 10000 , 7525 , 4067 , 238 , 6776 , 6777 , 5594 , 3932 , 5335 , 207 , 3055 , 6714 , 3718 , 2534 , 3717
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