Cell Signaling Technology Logo - Extra Large
View Featured Offers >>
  1. Products /
  2. Primary Antibodies /
  3. Ankyrin-B (F2A9R) Rabbit Monoclonal Antibody
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Ankyrin-B (F2A9R) Rabbit Monoclonal Antibody #67081

Filter:
  • IHC

    Product Specifications

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:1000 - 1:4000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Ankyrin-B (F2A9R) Rabbit Monoclonal Antibody recognizes endogenous levels of total ANKB protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human ANKB protein.

    Background

    Ankyrins are scaffolding proteins that recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. There are three members in the ankyrin gene family: Ankyrin-R (ANK1), Ankyrin-B (ANK2), and Ankyrin-G (ANK3) (1). Ankyrin-B (ANKB), primarily found in the heart and brain, is present in axons where it promotes the assembly of the axon initial segment (AIS) and functions to localize and stabilize cell adhesion molecules and ion channels along the axon (1,2). ANKB has been associated with neurological disorders such as autism spectrum disorder and epilepsy (3). This has been studied in ANK2-deficient mice that show spontaneous seizures and increased mortality (4). Furthermore, loss-of-function variants in the ANK2 gene are associated with a wide range of cardiac phenotypes, including arrhythmia, conduction abnormalities, and cardiomyopathy (2). 

    Alternate Names

    ANK-2; ANK2; ANKB; ankyrin 2; ankyrin 2, neuronal; ankyrin B; Ankyrin-2; ankyrin-2, nonerythrocytic; Ankyrin-B; ankyrin, brain; ankyrin, nonerythroid; Brain ankyrin; brank-2; CFAP87; DKFZp686M09125; DKFZp686P0948; FAP87; FLJ38277; LQT4; Non-erythroid ankyrin

    Database Links

    UniProt ID: Q01484


    Entrez-Gene Id: 287


    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.