AQP4 (D1F8E) Mouse Chimeric Monoclonal Antibody #55083
- IF
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Mouse chimeric IgG2a |
Application Key:
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Immunofluorescence (Frozen) | 1:200 - 1:800 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
The parent antibody, AQP4 (D1F8E) Rabbit Monoclonal Antibody #59678, is produced by immunizing animals with a recombinant protein specific to the carboxy terminus of human AQP4 protein.
Background
AQP4 is expressed in brain cells, including neurons, but enriched in astrocytes, as well as in the peripheral nervous system (4,7). AQP4 influences synaptic plasticity and the lack of this protein in the brain may cause memory and learning impairment via glutamate transporter 1 (GLT1) in Alzheimer's disease (8-10). It's suggested that AQP4 could play a role in the clearance of β-amyloid, and it may influence the transport of potassium and calcium in Alzheimer's disease (8,9). In Parkinson's disease, the lack of AQP4 results in an increased susceptibility of neurons from the substantia nigra and the ventral tegmental area for MPTP (11).
- Takata, K. et al. (2004) Prog Histochem Cytochem 39, 1-83.
- Echevarría, M. and Ilundáin, A.A. (1998) J Physiol Biochem 54, 107-18.
- Gomes, A. et al. (2018) Front Chem 6, 238.
- Xu, M. et al. (2017) Adv Exp Med Biol 969, 81-103.
- Kobayashi, H. et al. (2004) J Pharmacol Sci 96, 264-70.
- Meli, R. et al. (2018) Front Physiol 9, 101.
- Ishibashi, K. et al. (1998) Biochem Biophys Res Commun 244, 268-74.
- Hubbard, J.A. et al. (2018) Brain Res Bull 136, 118-129.
- Lan, Y.L. et al. (2016) Neural Plast 2016, 4626593.
- Lan, Y.L. et al. (2016) Mol Neurobiol 53, 5300-9.
- Zhang, J. et al. (2016) Neurosci Lett 614, 7-15.
Alternate Names
AQP-4; AQP4; aquaporin 4; aquaporin type4; Aquaporin-4; HMIWC2; Mercurial-insensitive water channel; MGC22454; MIWC; WCH4
Limited Uses
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