Render Target: STATIC
Render Timestamp: 2024-10-03T09:50:20.552Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ATL3 (F5T5J) Rabbit mAb #19901

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 60
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ATL3 (F5T5J) Rabbit mAb recognizes endogenous levels of total ATL3 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly519 of human ATL3 protein.

    Background

    Atlastin-3 (ATL3) is a dynamin-like, integral membrane GTPase that is localized to the endoplasmic reticulum (ER) membrane and critical for ER morphogenesis and tubular network biogenesis (1-3). ATL3 also functions as a cargo receptor for ER-phagy and promotes tubular ER degradation by specifically binding to GABARAP subfamily proteins. This ATL3-GABARAP interaction is essential for ATL3 to function in ER-phagy (4). Mutant ATL3 proteins are associated with hereditary sensory and autonomic neuropathies, illustrating the dependence of long-term sensory neuronal maintenance on the structural organization of the ER (5,6). Zika and coronavirus have been shown to modulate ER-phagy to drive viral replication by hijacking ATL3 and other ER-phagy receptors (7,8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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