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ATP2A1/SERCA1 (A988) Antibody

ATP2A1/SERCA1 (A988) Antibody #4274

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Supporting Data

REACTIVITY	M R
SENSITIVITY	Endogenous
MW (kDa)	100
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

ATP2A1/SERCA1 (A988) Antibody detects endogenous levels of total ATP2A1/SERCA1 protein.

Species Reactivity:

Mouse, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala988 of mouse ATP2A1/SERCA1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Sarcoplasmic and endoplasmic reticulum Ca²⁺ ATPases (SERCA) are members of a highly conserved family of Ca²⁺ pumps (1). SERCA pumps transport Ca²⁺ from the cytosol to the sarcoplasmic and endoplasmic reticulum lumen against a large concentration gradient (1). ATP2A1 (SERCA1) is a fast-twitch, skeletal muscle sarcoplasmic reticulum Ca²⁺ ATPase (2). Research studies have shown that mutations in the ATP2A1 gene cause an autosomal recessive muscle disorder known as Brody myopathy, which is characterized by muscle cramping and impaired muscle relaxation associated with exercise (1-3).

Database Links

UniProt ID: O14983

Entrez-Gene Id: 487

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For Research Use Only. Not For Use In Diagnostic Procedures.

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