Brain-Derived Tau (F6W7C) Rabbit Monoclonal Antibody #70448
- WB
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50-80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Brain-derived tau (BD-tau) originates from a brain-enriched MAPT splice variant that lacks exon 4a, which defines the peripheral high molecular weight isoform. BD-tau has been shown to be an effective fluid-based biomarker that selectively measures tau originating from the brain in both cerebrospinal fluid and plasma (4). Elevated plasma BD-tau levels reflect amyloid-associated neurodegeneration and, when combined with additional disease-relevant markers such as phosphorylated-tau, have the potential to stage AD and identify individuals with short-term cognitive decline and atrophy (5).
Alternate Names
DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MAPTL; MGC138549; microtubule associated protein tau; Microtubule-associated protein tau; MSTD; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; Tau iso8
Limited Uses
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