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Render Timestamp:
5/26/2026, 7:31:43 AM EDT
5/26/2026, 11:31:43 AM UTC
Commit: 7ed46ecc04b401f23a28df741b5078df405d23e4
XML generation date: 2025-11-12 16:13:10.941
Product last modified at: 2026-03-20T08:05:35.268Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

BSCL2/Seipin (D3W8C) Rabbit Monoclonal Antibody #23846

Filter:
  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 50
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    BSCL2/Seipin (D3W8C) Rabbit Monoclonal Antibody recognizes endogenous levels of total BSCL2/Seipin protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu383 of human BSCL2 protein.

    Background

    Seipin/BSCL2 is a homo-oligomeric membrane protein at the endoplasmic reticulum lipid droplet junction (1). Studies have demonstrated that Seipin/BSCL2 plays an important role in adipogenesis, lipid droplet homeostasis, liposis, brain development, and spermatogenesis. However, the exact function of BSCL2/Seipin is still not clear (2-5). BSCL2/Seipin is mutated in several human diseases, including Berardinelli-Seip congenital lipodystrophy, an autosomal recessive disorder characterized by a near absence of adipose tissues, severe insulin resistance, hypertriglyceridemia, hepatic steatosis, and early onset of diabetes (6-8).

    Alternate Names

    Berardinelli-Seip congenital lipodystrophy 2 (seipin); Bernardinelli-Seip congenital lipodystrophy 2 (seipin); Bernardinelli-Seip congenital lipodystrophy type 2 protein; BSCL2; BSCL2 lipid droplet biogenesis associated, seipin; BSCL2, seipin lipid droplet biogenesis associated; FLJ16651; GNG3LG; HMN5; MGC4694; PELD; Seipin; SPG17

    For Research Use Only. Not for Use in Diagnostic Procedures.
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