CA 19-9 (C241:5:1:4) Mouse mAb #68030
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Mouse IgG1 |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:400 - 1:1600 |
| Immunohistochemistry (Paraffin) | 1:800 - 1:3200 |
Storage
Protocol
Specificity / Sensitivity
CA 19-9 (C241:5:1:4) Mouse mAb recognizes endogenous levels of CA 19-9 protein. This antibody has minimal cross-reactivity (<1%) with sialyl lacto-N-tetraosylceramide. This antibody does not cross-react with Lewis A, Lewis B, or structurally-related substances.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with human colorectal adenocarcinoma Colo 205 cells.
Background
CA 19-9 specifically binds to the epitope of sialylated Lewis A carbohydrate structure, which is the functional ligand for E-selectin and is involved in the adhesion of cancer cells (1,2). The CA 19-9 antigen has been of clinical interest in detection, diagnosis, and management of cancers such as pancreatic and gastrointestinal carcinomas (3,4).
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