|9961T||1 Kit (6 x 20 microliters)||
|α-E-Catenin (23B2) Rabbit mAb 3240||20 µl||
||H M Mk||100||Rabbit IgG|
|N-Cadherin (D4R1H) XP® Rabbit mAb 13116||20 µl||
||H M||140||Rabbit IgG|
|E-Cadherin (24E10) Rabbit mAb 3195||20 µl||
||H M||135||Rabbit IgG|
|P-Cadherin (C13F9) Rabbit mAb 2189||20 µl||
|Pan-Cadherin (28E12) Rabbit mAb 4073||20 µl||
||H M R||130-150||Rabbit IgG|
|β-Catenin (D10A8) XP® Rabbit mAb 8480||20 µl||
||H M R Mk||92||Rabbit IgG|
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human α-E-catenin, residues surrounding Arg526 of human N-cadherin protein, residues near the carboxy terminus of human P-cadherin, residues surrounding 780 of human E-cadherin, residues surrounding Pro714 of human ß-catenin protein, and a synthetic peptide corresponding to a conserved region of human N-, R-, E- and P-Cadherin.
Adherens junctions are dynamic structures that form cell-cell contacts and are important in development, differentiation, tissue integrity, morphology and cell polarity. They are composed of cadherins that are transmembrane proteins that bind cadherins on adjacent cells in a calcium dependent manner. On the cytoplasmic side of adherens junctions, the cadherins associate with β-catenin, γ-catenin and p120 catenin (δ). β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). Recent studies indicate that cancer cells exhibit increased N-cadherin and diminished E-cadherin expression. E-cadherin is considered a suppressor of invasive cancer cell growth and this change in cadherin expression associated with cancer progression is termed the “cadherin switch”. β-catenin is one of the key downstream effectors in the Wnt signaling pathway and has been implicated in early embryonic development and tumorigenesis (3-5).
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