| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 9961T | 1 Kit (6 x 20 microliters) |
|
$ 518 |
| Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
|---|---|---|---|---|---|
| α-E-Catenin (23B2) Rabbit mAb 3240 | 20 µl |
|
H M Mk | 100 | Rabbit IgG |
| N-Cadherin (D4R1H) XP® Rabbit mAb 13116 | 20 µl |
|
H M | 140 | Rabbit IgG |
| E-Cadherin (24E10) Rabbit mAb 3195 | 20 µl |
|
H M | 135 | Rabbit IgG |
| P-Cadherin (C13F9) Rabbit mAb 2189 | 20 µl |
|
H | 120 | Rabbit IgG |
| Pan-Cadherin (28E12) Rabbit mAb 4073 | 20 µl |
|
H M R | 130-150 | Rabbit IgG |
| β-Catenin (D10A8) XP® Rabbit mAb 8480 | 20 µl |
|
H M R Mk | 92 | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Rab | Goat |
Product Information
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human α-E-catenin, residues surrounding Arg526 of human N-cadherin protein, residues near the carboxy terminus of human P-cadherin, residues surrounding 780 of human E-cadherin, residues surrounding Pro714 of human ß-catenin protein, and a synthetic peptide corresponding to a conserved region of human N-, R-, E- and P-Cadherin.
Adherens junctions are dynamic structures that form cell-cell contacts and are important in development, differentiation, tissue integrity, morphology and cell polarity. They are composed of cadherins that are transmembrane proteins that bind cadherins on adjacent cells in a calcium dependent manner. On the cytoplasmic side of adherens junctions, the cadherins associate with β-catenin, γ-catenin and p120 catenin (δ). β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). Recent studies indicate that cancer cells exhibit increased N-cadherin and diminished E-cadherin expression. E-cadherin is considered a suppressor of invasive cancer cell growth and this change in cadherin expression associated with cancer progression is termed the “cadherin switch”. β-catenin is one of the key downstream effectors in the Wnt signaling pathway and has been implicated in early embryonic development and tumorigenesis (3-5).
Explore pathways related to this product.
STRING - Known and Predicted Protein-Protein Interactions.
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