Render Target: STATIC
Render Timestamp:
5/26/2026, 6:12:00 AM EDT
5/26/2026, 10:12:00 AM UTC
Commit: 7ed46ecc04b401f23a28df741b5078df405d23e4
XML generation date: 2025-11-13 17:57:58.107
Product last modified at: 2026-03-20T08:04:39.596Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

CD105/Endoglin Antibody #3290

Filter:
  • WB

    Product Specifications

    REACTIVITY M
    SENSITIVITY Transfected Only
    MW (kDa) 79, 81
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CD105/Endoglin Antibody detects transfected levels of mouse CD105/Endoglin protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro430 of mouse CD105/Endoglin. Antibodies are purified by peptide affinity chromatography.

    Background

    CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and endothelial and stromal cells. Upregulated CD105/Endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in CD105/Endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6).

    Alternate Names

    AI528660; AI662476; CD105; Cell surface MJ7/18 antigen; Edg; EGLN; Endo; Endoglin; Eng; OTTMUSP00000012838; S-endoglin; transmembrane glycoprotein

    For Research Use Only. Not for Use in Diagnostic Procedures.
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