CD206/MRC1 (E6T5J) Feline Chimeric Monoclonal Antibody #53785
- IHC
- IF
Product Specifications
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Feline chimeric IgG1 |
Application Key:
- IHC-Immunohistochemistry
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) | 1:100 - 1:400 |
| Immunofluorescence (Frozen) | 1:400 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
This recombinant chimeric antibody is engineered from CD206/MRC1 (E6T5J) Rabbit Monoclonal Antibody #24595 according to animal-free protocols. The chimeric antibody retains its antigen-binding Fab regions from the original rabbit monoclonal antibody, but contains a feline-derived Fc domain. When multiplexing, Fc-directed rabbit secondaries are required to detect rabbit-host primary antibodies.
The parent antibody, CD206/MRC1 (E6T5J) Rabbit Monoclonal Antibody #24595, is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse CD206/MRC1 protein.
Background
- Martinez-Pomares, L. (2012) J Leukoc Biol 92, 1177-86.
- Lennartz, M.R. et al. (1989) J Biol Chem 264, 2385-90.
- Wileman, T.E. et al. (1986) Proc Natl Acad Sci U S A 83, 2501-5.
- Taylor, M.E. et al. (1990) J Biol Chem 265, 12156-62.
- Fiete, D.J. et al. (1998) Proc Natl Acad Sci U S A 95, 2089-93.
- Napper, C.E. et al. (2006) Biochem J 395, 579-86.
- Fiete, D. et al. (1997) Proc Natl Acad Sci U S A 94, 11256-61.
- Tietze, C. et al. (1982) J Cell Biol 92, 417-24.
- Burgdorf, S. et al. (2006) J Immunol 176, 6770-6.
- Lee, S.J. et al. (2002) Science 295, 1898-901.
- Milone, M.C. and Fitzgerald-Bocarsly, P. (1998) J Immunol 161, 2391-9.
- Marttila-Ichihara, F. et al. (2008) Blood 112, 64-72.
Alternate Names
AW259686; CD206; Macrophage mannose receptor 1; mannose receptor, C type 1; MMR; MR; Mrc1; OTTMUSP00000012205
Limited Uses
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