CD3 gamma (F1D9A) Rabbit Monoclonal Antibody #36193
- WB
- IP
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 25, 20 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
CD3γ is one of the invariant chains of the TCR signaling complex and is expressed at the cell surface as a type-I transmembrane glycoprotein, which forms a non-covalent heterodimer with CD3ε. Like other invariant chains of the TCR signaling complex, CD3γ contains a single ITAM with two embedded tyrosine residues that are likely directly phosphorylated by members of the Src family of tyrosine kinases to facilitate T cell activation (6,7). Research studies have demonstrated that CD3γ is also phosphorylated on serine residues, constituting a mechanism to downregulate TCR signaling through receptor internalization (8).
- Kuhns, M.S. et al. (2006) Immunity 24, 133-139.
- Pitcher, L.A. and van Oers, N.S. (2003) Trends Immunol. 24, 554-560.
- Osman, N. et al. (1996) Eur. J. Immunol. 26, 1063-1068.
- Hatada, M.H. et al. (1995) Nature 377, 32-38.
- Gil, D. et al. (2002) Cell 109, 901-912.
- Barber, E.K. et al. (1989) Proc Natl Acad Sci USA 86, 3277-81.
- Alarcón, B. et al. (1991) EMBO J 10, 903-12.
- Dietrich, J. et al. (1994) EMBO J 13, 2156-66.
Alternate Names
CD3-GAMMA; CD3G; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); FLJ17620; FLJ17664; FLJ79544; FLJ94613; IMD17; MGC138597; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain; T3G
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