Render Target: STATIC
Render Timestamp: 2024-12-06T12:01:00.845Z
Commit: 224419269841c11382c4555dbee545259bf6c379
XML generation date: 2024-04-05 20:37:16.508
Product last modified at: 2024-10-07T14:45:10.405Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

CD59 Antibody #65055

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 18
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CD59 Antibody recognizes endogenous levels of total CD59 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln99 of human CD59 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    CD59 is a GPI-anchored membrane protein that functions as an inhibitor of the complement membrane attack complex (MAC). CD59 binds to complement components C8 and C9, preventing C9 polymerization and insertion into membranes, therefore inhibiting the complement-dependent cytolysis (CDC) (1). CD59 is a ubiquitously expressed cell membrane protein that protects cells from CDC. Rare cases of CD59 deficiency have been reported to cause paroxysmal nocturnal hemoglobinuria in human patients (2,3). Expression of CD59 on tumor cells and viral infected cells makes them resist antibody-dependent complement-mediated lysis. Potent inhibitors for CD59 have been actively pursued for therapeutic applications (4,5). In addition, CD59 may regulate insulin secretion by modulating exocytosis (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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