CDX2 Antibody #3977
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 38 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
CDX2 Antibody detects endogenous levels of total CDX2 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids at the N-terminus of human CDX2. Antibodies are purified by Protein A and peptide affinity chromatography.
Background
CDX2, a homeobox domain-containing transcription factor, is a master regulator of the trophectoderm, the layer that gives rise to extra-embryonic tissues in mammalian development (1). CDX2 is also involved in intestinal development (2), and gain of expression or loss of expression has been associated with various human malignancies, such as Barrett's esophagus (3) and colorectal cancer (4,5). Mouse embryonic stem cells deficient in CDX2 display limited hematopoietic progenitor development and altered Hox gene expression (6), pointing to a role for CDX2 in Hox gene regulation. CDX2 is also implicated in the aberrant expression of Hox genes in human AML cell lines (7).
- Ralston, A. and Rossant, J. (2008) Dev Biol 313, 614-29.
- Traber, P.G. and Silberg, D.G. (1996) Annu Rev Physiol 58, 275-97.
- Shi, X.Y. et al. (2008) Am J Clin Pathol 129, 571-7.
- Bakaris, S. et al. (2008) Histol Histopathol 23, 1043-7.
- Guo, R.J. et al. (2004) Cancer Biol Ther 3, 593-601.
- Wang, Y. et al. (2008) Proc Natl Acad Sci U S A 105, 7756-61.
- Fröhling, S. et al. (2007) Cell Cycle 6, 2241-5.
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