CHMP2B (D4G3K) Rabbit Monoclonal Antibody #76173
- WB
- IP
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Research studies have shown that mutation of CHMP2B is associated with frontotemporal dementia, (5, 6). Studies have further shown that the dysfunction of mutant CHMP2B expression may disrupts the normal endo-autophagosome and endo-lysosome pathways and lead to neurodegenerative diseases (6-9).
- McCullough, J. et al. (2013) Annu Rev Biochem 82, 663-92.
- Henne, W.M. et al. (2013) Cold Spring Harb Perspect Biol 5, (9).
- Henne, W.M. et al. (2012) Cell 151, 356-71.
- Bodon, G. et al. (2011) J Biol Chem 286, 40276-86.
- Skibinski, G. et al. (2005) Nat Genet 37, 806-8.
- Lee, J.A. et al. (2007) Curr Biol 17, 1561-7.
- Filimonenko, M. et al. (2007) J Cell Biol 179, 485-500.
- Han, J.H. et al. (2012) Biochem Biophys Res Commun 421, 544-9.
- Urwin, H. et al. (2010) Hum Mol Genet 19, 2228-38.
Alternate Names
ALS17; Charged multivesicular body protein 2b; CHM2B; CHMP2.5; CHMP2B; chromatin modifying protein 2B; Chromatin-modifying protein 2b; DKFZp564O123; DMT1; hVps2-2; Vacuolar protein sorting-associated protein 2-2; vacuolar protein-sorting-associated protein 2-2; VPS2 homolog B; Vps2-2; VPS2B
Limited Uses
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