CPSF6 Antibody #75168
- WB
- IP
Product Specifications
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 68 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
CPSF6 is a 68 kDa member of the CPSF group that has been shown to target the HIV-1 viral capsid (CA) (6). A truncated form of CPSF6, CPSF6-358, localizes exclusively in the cytoplasm and can oligomerize to bind CA, restricting HIV infection and nuclear entry (7,8).
- Rüegsegger, U. et al. (1996) J Biol Chem 271, 6107-13.
- Murthy, K.G. and Manley, J.L. (1992) J Biol Chem 267, 14804-11.
- Bienroth, S. et al. (1993) EMBO J 12, 585-94.
- Hirose, Y. and Manley, J.L. (1998) Nature 395, 93-6.
- Nemeroff, M.E. et al. (1998) Mol Cell 1, 991-1000.
- Lee, K. et al. (2010) Cell Host Microbe 7, 221-33.
- Lee, K. et al. (2012) J Virol 86, 3851-60.
- Ning, J. et al. (2018) J Virol 92.
Alternate Names
CFIM; CFIM68; CFIM72; cleavage and polyadenylation specific factor 6; cleavage and polyadenylation specific factor 6, 68kDa; Cleavage and polyadenylation specificity factor 68 kDa subunit; Cleavage and polyadenylation specificity factor subunit 6; Cleavage factor Im complex 68 kDa subunit; CPSF 68 kDa subunit; CPSF6; HPBRII-4; HPBRII-7; pre-mRNA cleavage factor I, 68kD subunit; pre-mRNA cleavage factor Im (68kD); Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPBRII-4/7
Limited Uses
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