Render Target: STATIC
Render Timestamp: 2024-11-01T09:40:53.726Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-25 17:06:08.107
Product last modified at: 2024-10-25T18:45:12.196Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CXCL13 (F6A4R) Rabbit mAb #85679

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 13
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:300 - 1:1200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CXCL13 (F6A4R) Rabbit mAb recognizes endogenous levels of total CXCL13 protein. This antibody detects 58 and 75 kDa bands of unknown origin in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CXCL13 protein.

    Background

    C-X-C motif chemokine ligand 13 (CXCL13), also known as B cell-attracting chemokine 1 (BCA-1), is a chemokine expressed primarily by follicular dendritic cells of secondary lymphoid organs such as lymph nodes (LNs), Peyer’s patches, and spleen (1,2). CXCL13 is the ligand for CXCR5, and upon binding, the CXCL13/CXCR5 axis is required for B cell activation, migration, and homeostasis (1-4). Dysregulated CXCL13 expression has been associated with autoimmunity, cancer, and infectious diseases, making it a potential therapeutic target (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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