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CXCR5 (E3G3A) Rabbit Monoclonal Antibody #78862

Filter:
  • F

    Product Specifications

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Flow Cytometry (Live) 1:200 - 1:800

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CXCR5 (E3G3A) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCR5 protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of mouse CXCR5 protein.

    Background

    CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and responds to CXCL13 gradient to control lymphocyte migration toward secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4).

    Alternate Names

    Blr1; Burkitt lymphoma receptor 1 homolog; C-X-C chemokine receptor type 5; CD185; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; CXC-R5; CXCR-; CXCR-5; Cxcr5; Gpc; Gpcr6; MDR15

    For Research Use Only. Not for Use in Diagnostic Procedures.
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