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REACTIVITY SENSITIVITY MW (kDa) SOURCE
70 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Deltex-2 Antibody detects transfected levels of total Deltex-2 protein.


Species predicted to react based on 100% sequence homology: Human, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala607 of human Deltex-2. Antibodies are purified by protein A and peptide affinity chromatography.

Deltex (DTX) encodes a putative E3 ubiquitin ligase first identified from Drosophila and shown to modulate Notch signaling (1). Several mammalian Deltex homologs have been isolated (2,3), all containing a pair of WWE repeats, a proline-rich region, and a Ring-finger domain (4,5). Deltex binds to the ankyrin-repeat domain of Notch and is capable of regulating Notch signaling positively or negatively in different systems (4,6). In addition, Deltex can also form homo-multimers (4). While Deltex has been implicated in Notch signaling regulation of lymphocyte development, this signal modifier may also have a transcriptional function independent of Notch (3, 6-8).


1.  Xu, T. and Artavanis-Tsakonas, S. (1990) Genetics 126, 665-77.

2.  Kishi, N. et al. (2001) Int J Dev Neurosci 19, 21-35.

3.  Lehar, S.M. and Bevan, M.J. (2006) Mol Cell Biol 26, 7358-71.

4.  Matsuno, K. et al. (1995) Development 121, 2633-44.

5.  Zweifel, M.E. et al. (2005) Structure 13, 1599-611.

6.  Izon, D.J. et al. (2002) Immunity 16, 231-43.

7.  Yun, T.J. and Bevan, M.J. (2003) J Immunol 170, 5834-41.

8.  Yamamoto, N. et al. (2001) J Biol Chem 276, 45031-40.


Entrez-Gene Id 113878
Swiss-Prot Acc. Q86UW9


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

2663
Deltex-2 Antibody