|Myelin Basic Protein (E9P7U) Mouse mAb 83683||20 µl||
||H M R||12-18||Mouse IgG2b kappa|
|PLP1 (E9V1N) Rabbit mAb 28702||20 µl||
||H M R||20-30||Rabbit IgG|
|MOG (E5K6T) XP® Rabbit mAb 96457||20 µl||
||H M R||46, 35, 28, 23||Rabbit IgG|
|MAG (D4G3) XP® Rabbit mAb 9043||20 µl||
||H M R||100||Rabbit IgG|
|Caspr (D8I3V) Rabbit mAb 97736||20 µl||
||H M R||190||Rabbit IgG|
|Caspr2 (D6S1O) Rabbit mAb 61962||20 µl||
||H M R||150||Rabbit IgG|
|Neurofascin 155 (D7B6O) Rabbit mAb 15035||20 µl||
||H M R||140-155||Rabbit IgG|
|Neurofascin 186 (D6G6O) Rabbit mAb 15034||20 µl||
||H M R||200||Rabbit IgG|
|β3-Tubulin (D71G9) XP® Rabbit mAb 5568||20 µl||
||H M R||55||Rabbit IgG|
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Monoclonal antibodies are produced by immunizing rabbits with synthetic peptides corresponding to Arg188 of human MBP protein, Arg605 of human MAG protein, Pro1375 of human Caspr protein, Gln1040 of human Caspr2 protein, Arg881 of human neurofascin 155 protein, Thr1108 of human neurofascin 186 protein, residues near the carboxy terminus of human PLP1 protein, and the carboxy terminus of human β3-tubulin protein. MOG (E5K6T) XP® Rabbit mAb is produced by immunizing animals with recombinant protein specific to the extracellular membrane proximal amino terminus of human MOG protein.
Myelin is the insulating material surrounding neuronal axons. The function of myelin is to promote action potential propagation down the axon to the axon terminal. Myelin is formed in the central nervous system (CNS) by specialized glial cells called oligodendrocytes and by Schwann cells in the peripheral nervous system (PNS). Oligodendrocytes and Schwann cells make concentric rings, called the myelin sheath, around the axon at regular intervals. These intervals, called nodes of ranvier, are enriched in structural proteins and ion channels, which help promote action potential propagation. Several proteins are enriched in the myelin sheath and likely help mediate the tight multi-layered membranes that make up the sheath. These proteins include myelin basic protein (MBP, ), myelin-associated glycoprotein (MAG, ), myelin proteolipid protein (PLP1, ) and myelin-oligodendrocyte glycoprotein (MOG, ). Contactin-associated protein (Caspr) 1 & 2 (5,6) and neurofascin 155 & 186 (7,8) are nodes of ranvier-associated proteins that may play roles in generating the regular intervals of myelin along the axon. Expression of several of these proteins are altered in demyelinating diseases such as multiple sclerosis (MS). Additionally, mislocalization and/or altered expression of these proteins, compared to the axonal protein β3-tubulin, may represent altered myelin function.
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