Render Target: STATIC
Render Timestamp: 2024-12-09T11:28:46.308Z
Commit: 224419269841c11382c4555dbee545259bf6c379
XML generation date: 2024-09-30 01:58:14.590
Product last modified at: 2024-10-28T08:30:09.525Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

DHODH (E9X8R) Rabbit mAb #26381

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 43
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    DHODH (E9X8R) Rabbit mAb recognizes endogenous levels of total DHODH protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly301 of human DHODH protein.

    Background

    Dihydroorotate dehydrogenase (DHODH) catalyzes the conversion of dihydroorotate to orotate in pyrimidine biosynthesis. DHODH was shown to be a metabolic regulator of myeloid differentiation in AML models. Inhibition of this enzyme triggers myeloid differentiation, decreases leukemic cell burden, and prolongs survival (1). In addition, research studies show that pyrimidine biosynthesis mediated by DHODH is critical for tumorigenesis. Cancer cells deleted of DHODH fail to form tumors, suggesting DHODH as a potential target in cancer therapy (2). Further studies also indicate that loss of DHODH diminishes tumor growth in vivo (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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