DNTT (F5U7V) Rabbit Monoclonal Antibody #66759
- WB
Product Specifications
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Recent work has focused on the role of DNTT in immune cell function and cancers (5). DNTT has been shown to play a role in the differentiation of stem cells into mucosal-associated invariant T cells (MAITs) (6). Patients with leukemias and lymphomas have high expression of DNTT (7,8), and low expression of DNTT is significantly associated with increased resistance to chemotherapy in B-cell acute lymphoblastic leukemia (B-ALL) patients (8).
- Isobe, M. et al. (1985) Proc Natl Acad Sci USA 82, 5836-40.
- Motea, E.A. and Berdis, A.J. (2010) Biochim Biophys Acta 1804, 1151-66.
- Zhang, Y. et al. (2012) Cell Immunol 274, 19-25.
- Haeryfar, S.M. et al. (2008) J Immunol 181, 649-59.
- Berdis, A.J. (2008) Biochemistry 47, 8253-60.
- Saito, Y. et al. (2017) PLoS One 12, e0174699.
- Thomson, D.W. et al. (2020) Leukemia 34, 2051-2063.
- Escherich, C.S. et al. (2025) Blood 145, 1182-1194.
Alternate Names
deoxynucleotidyltransferase, terminal; DNA nucleotidylexotransferase; DNTT; nucleosidetriphosphate:DNA deoxynucleotidylexotransferase; TDT; Terminal addition enzyme; Terminal deoxynucleotidyltransferase; terminal deoxyribonucleotidyltransferase; Terminal transferase
Limited Uses
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