|MMP-1 (E9S9N) Rabbit mAb 54376||20 µl||
|MMP-2 (D4M2N) Rabbit mAb 40994||20 µl||
|MMP-9 (D6O3H) XP® Rabbit mAb 13667||20 µl||
||H||84, 92||Rabbit IgG|
|MMP-13 (E4W3T) Rabbit mAb 69926||20 µl||
|Fibronectin/FN1 (E5H6X) Rabbit mAb 26836||20 µl||
|MMP-3 (D7F5B) Rabbit mAb 14351||20 µl||
||H R||60||Rabbit IgG|
|LOX (D8F2K) Rabbit mAb 58135||20 µl||
||H M||54, 56||Rabbit IgG|
|COL11A1 (E6O7R) Rabbit mAb 70458||20 µl||
|COL1A1 (E6A8E) Rabbit mAb 39952||20 µl||
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Monoclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val267 of human MMP-1 protein, Phe542 of human MMP-9 protein, Ser417 of human MMP-3 protein, carboxyl terminal region of human MMP13 protein, Glu320 of human COL11A1 protein, Lys170 of human COL1A1 protein, recombinant protein specific to the carboxy terminus of human MMP-2 protein, recombinant protein specific to the carboxy terminus of human FN1 protein, and a recombinant protein specific to human LOX protein.
The extracellular matrix (ECM) is a cell surface associated three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins (1). The network provides a dynamic microenvironment surrounding the cell enabling it to carry on its function. Among the ECM proteins, fibronectin functions as a mediator to bridge distinct ECM components such as collagens, growth factors, as well as cell surface integrins to regulate ECM structural change and initiate signaling pathways (2). During normal development and pathological conditions, the ECM network is highly dynamic and continuously undergoes remodeling marked by the change of the ECM structural components, such as COL1A1, COL11A1, fibronectin, and versican. The matrix-degrading enzyme MMPs such as MMP1, MMP2, and MMP9 are highly involved in this process (4). Additional players in this process are the LOX family members of lysyl oxidase. They catalyze the first step of the covalent cross-linking of ECM proteins, collagens, and elastin, which contributes to ECM stiffness and mechanical properties (5).
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