| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 17257S | 1 Kit |
|
| REACTIVITY | H |
| Product Includes | Quantity | Isotype | |||
|---|---|---|---|---|---|
| EGF Receptor (E746-A750del Specific) (D6B6) XP® Rabbit mAb (BSA and Azide Free) 53177 | 100 µg | Rabbit IgG | |||
| EGF Receptor (C74B9) Rabbit mAb (BSA and Azide Free) | 100 µg | Rabbit IgG |
Product Information
The EGF Receptor (E746-A750del Specific) Matched Antibody Pair is ideal for use with immunoassay technologies and high-throughput ELISA platforms requiring antibody pairs with specialized or custom antibody labeling. Labels include fluorophores, lanthanides, biotin, and beads. Platforms requiring conjugated Matched Antibody Pairs include MSD, Quanterix Simoa, Alpha Technology (AlphaScreen, AlphaLISA, LANCE, HTRF), and Luminex.
Learn how Matched Antibody Pairs move your projects forward, faster at cst-science.com/matched-antibody-pairs.
The epidermal growth factor (EGF) receptor is a 170 kDa transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Research studies have shown that somatic mutations in the tyrosine kinase domain of EGF receptor (EGFR) are present in a subset of lung adenocarcinomas that respond to EGFR inhibitors, such as gefitinib and erlotinib (1-3). Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, that occurs in exon 21 and short in-frame deletions in exon 19 (4,5). The most frequent exon 19 deletion is E746-A750, accounting for 90% of lesions at this site, although some rare variants occur.
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STRING - Known and Predicted Protein-Protein Interactions.
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