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EXOSC10 (F4Q2B) Rabbit Monoclonal Antibody #34735

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    EXOSC10 (F4Q2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total EXOSC10 protein. This antibody detects a 32 kDa band of unknown origin.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly877 of human EXOSC10 protein.

    Background

    Exosome component 10 (EXOSC10), also known as RRP6 or autoantigen PM/Scl-100, is a 3’-5’ nuclear component of the exosome complex with 3’-5’ exonuclease activity. EXOSC10 is essential for the 3’ end formation of 5.8S rRNA, as well as the degradation of improperly spliced or polyadenylated mRNAs (1-3). Additionally, EXOSC10 regulates the proper 3’ formation of small nucleolar RNAs (snoRNAs) (4). EXOSC10 is the antibody target in polymyositis-scleroderma overlap, an autoimmune disease (5-7).

    Alternate Names

    autoantigen PM-SCL; Autoantigen PM/Scl 2; EXOSC10; Exosome complex component 10; Exosome component 10; EXOSX; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; polymyositis/scleroderma autoantigen 2 (100kD); polymyositis/scleroderma autoantigen 2, 100kDa; RRP6; Rrp6p

    For Research Use Only. Not for Use in Diagnostic Procedures.
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