Cell Signaling Technology Logo - Extra Large
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FABP6 (F9U9N) Rabbit Monoclonal Antibody #59089

Filter:
  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 12, 15
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FABP6 (F9U9N) Rabbit mAb recognizes endogenous levels of total FABP6 protein. This antibody detects a 130 kDa protein of unknown identity in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val41 of human FABP6 protein.

    Background

    Fatty acid-binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones. They participate in the transport of fatty acids and other lipids to various cellular pathways (1). They are critical mediators of metabolic processes and are increasingly being understood to play key roles in disease (2). Fatty acid-binding protein 6 (FABP6), also known as ileal bile acid-binding protein (I-BABP), is highly expressed in the ileum, where it binds bile acid and regulates the ileal bile acid transport system (3,4). FABPs play a role in cancer initiation and progression, and FABP6 has been identified as a potential therapeutic target and prognostic marker for multiple cancers (5-7). In a study of tumor immune infiltration in colorectal cancer (CRC), knockdown of FABP6 promoted the recruitment of CD8+ T cells via enhancing the immunogenicity of tumor cells and promoting chemokine secretion (8).

    Alternate Names

    FABP6; fatty acid binding protein 6; fatty acid binding protein 6, ileal; Fatty acid-binding protein 6; Gastrotropin; GT; I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ileal bile acid binding protein; Ileal lipid-binding protein; ILLBP; illeal lipid-binding protein; Intestinal 15 kDa protein; Intestinal bile acid-binding protein

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.