|9330T||1 Kit (4 x 20 microliters)||
|Phospho-FAK (Tyr576/577) Antibody 3281||20 µl||
||H M R||125||Rabbit|
|Phospho-FAK (Tyr925) Antibody 3284||20 µl||
|Phospho-FAK (Tyr397) (D20B1) Rabbit mAb 8556||20 µl||
|FAK (D2R2E) Rabbit mAb 13009||20 µl||
||H M||125||Rabbit IgG|
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Monoclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr397 of human FAK protein and a synthetic peptide corresponding to residues surrounding Ser893 of human FAK protein. Polyclonal antibodies are produced by immunizing animals with synthetic phosphopeptides corresponding to residues surrounding Tyr576/577 and Tyr925 of human FAK protein.
Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival (1). Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ (2-5). Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK (6,7).
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UniProt ID: Q05397
Entrez-Gene Id: 5747
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