Render Target: STATIC
Render Timestamp: 2024-10-11T09:37:21.332Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-06 12:31:11.520
Product last modified at: 2024-09-24T12:00:11.550Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

FKBP5 Antibody #8245

Filter:
  • WB

    Supporting Data

    REACTIVITY H M Mk
    SENSITIVITY Endogenous
    MW (kDa) 51
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FKBP5 Antibody recognizes endogenous levels of total FKBP5 protein. This antibody does not cross-react with FKBP4 protein.

    Species Reactivity:

    Human, Mouse, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human FKBP5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to the FKBP family of immunophilins (1). FKBP family proteins contain FK domains and TPR (tetratricopeptide repeat) domains. The FK domains are responsible for PPIase (peptidylprolyl isomerase) activity and allow binding to FK506 and rapamycin (2,3). The C terminal TPR domains are involved in protein-protein interactions. The TPR domain of FKBP5 mediates binding to HSP90 complexes (4), as well as glucocorticoid, androgen, and progesterone receptors, which account for its regulatory role in steroid hormone receptor function (5). FKBP5 also binds to IKKα and is involved in NF-κB signaling (6,7). In addition, FKBP5 was identified as a negative regulator of Akt through promotion of Akt - PHLPP interaction and enhanced dephosphorylation of Akt (8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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