Name: FNIP2 (D3T8Z) Rabbit mAb
Price: 339.00 USD
Availability: InStock

Filter:

WB
IP

Supporting Data

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	140
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

FNIP2 (D3T8Z) Rabbit mAb recognizes endogenous levels of total FNIP2 protein. This antibody does not cross-react with FNIP1 protein.

Species Reactivity:

Human, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly26 of human FNIP2 protein.

Background

FNIP1 and FNIP2 were identified as proteins interacting with tumor suppressor folliculin (FLCN) (1-3). FNIP1 and FNIP2 directly associate with AMPK, which indicates that they play roles in the energy and nutrient sensing pathways (1, 2). Further studies show that the FLCN/FNIP2 complex functions as a GTPase-activating protein for Rag GTPase C and Rag GTPase D (4). FLCN/FNIP2 complex thus promotes the binding of mTORC1 to Rag heterodimers, leading to the mTORC1 activation (4). In addition, along with FLCN, both FNIP1 and FNIP2 contribute to kidney tumor suppression (5).

Alternate Names

FNIP1-like protein; FNIP2; FNIPL; folliculin interacting protein 2; Folliculin-interacting protein 2; KIAA1450; MAPO1

Database Links

UniProt ID: Q9P278

Entrez-Gene Id: 57600

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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FNIP2 (D3T8Z) Rabbit mAb #57612