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Commit: 7ed46ecc04b401f23a28df741b5078df405d23e4
XML generation date: 2026-04-06 11:51:10.913
Product last modified at: 2026-03-20T08:12:04.820Z
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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a
  1. Products /
  2. Primary Antibodies /
  3. Fragile X/FMRP Signaling Pathway Antibody Sampler Kit

Fragile X/FMRP Signaling Pathway Antibody Sampler Kit #48267

    Product Information

    Kit Usage Information

    Protocols

    Product Description

    The Fragile X/FMRP Signaling Pathway Antibody Sampler Kit provides an economical means of detecting signaling components of the Fragile X/FMRP signaling pathway. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.

    Background

    Fragile X syndrome, a frequent cause of inherited mental retardation, often results from expansion of the CGG trinucleotide repeat in the gene that encodes the fragile X mental retardation protein (FMRP, [1]). FMRP (also known as FMR1) and its two autosomal homologs (FXR1 and FXR2) all bind RNA and play a role in the pathogenesis of fragile X syndrome (1-3). Each of these related proteins can associate with one another as well as form homodimers and complexes with other RNA-binding proteins like cytoplasmic FMRP interacting protein 1 (CYFIP1, [3,4]). FMRP, FXR1, FXR2, and CYFIP1 have been implicated in the translational regulation of mRNAs (5,6). Importantly, this complex of proteins may be dynamically regulated to drive protein synthesis-dependent forms of synaptic plasticity in response to specific activity. That is, activation of metabotropic glutamate receptors, including mGluR1 and mGlur5, can regulate FMRP-dependent forms of translation via post-translational modification of eukaryotic elongation factor 2 (eEF2) to locally control dynamic translation of important synaptic proteins, which, subsequently, alter synaptic function (7-9).   

    Database Links

    UniProt ID: P51114 , P41594 , Q06787 , P13639 , Q13255 , Q7L576 , P51116


    Entrez-Gene Id: 8087 , 2915 , 2332 , 1938 , 2911 , 23191 , 9513


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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